Cancer describes a set of diseases in which normal cells in the body, through a series of genetic
changes, lose the ability to control their growth and to respect their neighbors. As cancers grow,
they invade the tissues around them (local invasion). They may also spread to other locations in
the body via the blood vessels or lymphatic channels where they may implant and grow (metastases).
Tumors, or growths in the body, may be benign or malignant (cancerous). When they are benign they
may grow but they do not spread to other locations. Malignant tumors have the ability to invade
deeply and to spread (metastasize).
Anal cancer arises from the cells around the anal opening (verge) or within the anal canal (1-2
inches long) up to its junction with the rectum. Most anal cancers arise from skin cells and are
called squamous cell carcinomas. Some arise from the special mucosal cells lining the upper anal
canal and are called cloacogenic carcinomas. Although several other types of cancer may occur in
this area, these two are the most common. They behave similarly and are treated in the same fashion.
Cells that are becoming malignant but have not invaded below the surface are "pre-cancerous"
(carcinoma-in-situ). This condition is called Bowen's disease.
Anal cancer is fairly uncommon. It accounts for about 1-2% of gastrointestinal cancers. About 3,400
new cases of anal cancer are diagnosed each year in the U.S.A., and about 500 people will die of
the disease each year. This may be compared to 140,000 new cases of colorectal cancer with 50,000
deaths per year.
We do not know the exact cause of most anal cancers. But we do know that certain risk factors
are linked to anal cancer. A risk factor is something that increases a person's chance of
getting a disease.
- Age - Most people with anal cancer are over 50 years old.
- Anal warts - Infection with the human papilloma virus (HPV) which causes condyloma (warts)
may increase the chance of developing anal cancer.
- Anal sex - Persons who participate in anal sex are at an increased risk.
- Smoking - Harmful chemicals from smoking increase the risk of most cancers including anal
- Immunosuppression - People with weakened immune systems, such as transplant patients who must
take drugs to suppress their immune systems and patients with HIV (human immunodeficiency virus)
infection, are at a somewhat higher risk.
- Chronic local inflammation - People with long-standing anal fistulas or open wounds are at a
slightly higher risk.
- Pelvic radiation - People who have had pelvic radiation therapy for rectal, prostate, bladder
or cervical cancer are at an increased risk.
Few cancers can be totally prevented but your risk may be decreased significantly by reducing your
risk factors and by getting regular checkups. Avoid anal sex and infection with HPV and HIV. Use
condoms whenever having any kind of intercourse. Although condoms do not eliminate the risk of
infection, they do reduce it. Stopping smoking lowers the risk of many types of cancer, including
Many cases of anal cancer can be found early. Anal cancers form in a part of the digestive tract
that the doctor can see and reach easily. Anal cancers often cause symptoms such as:
- Bleeding from the rectum or anus
- The feeling of a lump or mass at the anal opening
- Pain in the anal area
- Persistent or recurrent itching
- Change in bowel habits (having more or fewer bowel movements) or increased straining during a
- Narrowing of the stools
- Discharge (mucous or pus) from the anus
- Swollen lymph nodes (glands) in the anal or groin areas.
These symptoms can also be caused by less serious conditions such as hemorrhoids but you should
never assume this. If you have any of these symptoms, see your doctor.
Finding cancers early is the key to cure. Regular checkups with a digital (finger) exam of the
rectum and anus will find many problems which are easy to treat when found early. Routine screening
for colorectal and anal cancer in people without any symptoms includes a digital rectal exam and
test for blood in the stool yearly and a flexible endoscopy exam (lighted probe) every 5-10 years
starting at 50 years of age.
If anal cancer is suspected based on your doctor’s exam, a biopsy will be performed to confirm
the diagnosis. If the diagnosis of cancer is confirmed, additional tests to determine the extent
of the cancer may be recommended.
Treatment for most cases of anal cancer is very effective. There are 3 basic types of treatment
used for anal cancer:
- surgery ?an operation to remove the cancer
- radiation therapy ?high-dose x-rays to kill cancer cells, and
- chemotherapy ?giving drugs to kill cancer cells.
Combination therapy including radiation therapy and chemotherapy is now considered the standard
treatment for most anal cancers. Occasionally a very small or early tumor may be removed
surgically (local excision), with minimal damage to the anal sphincter muscles.
The majority of patients treated for anal cancer will not need a colostomy. If the tumor does
not respond completely to combination therapy, if it recurs after treatment, or if it is an
unusual type, an abdomino-perineal resection (APR) removal of the rectum and anus and creation
of a colostomy may be necessary.
Follow-up care to assess the results of treatment and to check for recurrence is very important.
Most anal carcinomas are effectively treated. In addition, many tumors that recur may be
successfully treated if they are caught early. A careful examination by an experienced physician
at regular intervals is the most important method of follow-up. Additional studies may be
recommended. You should report any symptoms or problems to your doctor right away.
Anal cancers are unusual tumors arising from the skin or mucosa of the anal canal. As with most
cancers, early detection is associated with excellent survival. Most tumors are well treated with
combination chemotherapy and radiation. Recurrences may often be treated successfully. Follow the
recommended screening examinations for anal and colorectal cancer and consult your doctor early
when any anorectal symptoms occur.